Izoliatoriai yra švaraus oro įrenginiai, užtikrinantys visišką atskyrimą tarp aseptinio proceso (pavojingo / nepavojingo), techninio personalo ir supančios darbo aplinkos. Izoliatoriai paprastai naudojami taikymo srityse, kuriose reikalingas aukštas apsaugos nuo išorinių veiksnių ar teršalų lygis, ir jie gali būti alternatyva sudėtingoms švariosioms patalpoms.
Izoliatoriuose paprastai įrengtos integruotos oro filtravimo sistemos, galinčios gerokai sumažinti dalelių skaičių uždaroje erdvėje. Santykinai kompaktiškas izoliatoriaus vidaus dydis leidžia lengviau jį valyti dujinėmis ar garų sterilizavimo priemonėmis. Priklausomai nuo taikymo srities, izoliatoriai gali būti sukonfigūruoti su teigiamu arba neigiamu slėgiu supančios aplinkos atžvilgiu. Teigiamo slėgio izoliatoriai užtikrina produkto apsaugą nuo teršalų, taip išlaikydami sterilumą; tuo tarpu neigiamo slėgio izoliatoriai, priešingai, užtikrina personalo ir (arba) aplinkos apsaugą, sulaikydami pavojingas ar toksiškas medžiagas izoliatoriaus viduje.
Aseptic Isolators are critical for providing an isolated ISO Class 5/Grade A environment required for manufacturing sterile products and carrying out aseptic processes. These isolators feature automated pressure hold tests, automated H2O2 bio-decontamination, and continuous environmental monitoring to ensure process sterility.
Applications
- Cell Therapy, Bioprocessing, and Cell Culture
- Pharmaceutical Manufacturing & Formulation
- Sterility Testing & QC Laboratories
- Electronics & Semiconductor Clean Processing
Containment Isolators utilize a negative pressure airflow system engineered for the safe handling of high-potency active pharmaceutical ingredients (HPAPIs) and toxic compounds. Built with breach compensation mechanisms and automated pressure testing, operator and environmental safety remains the top priority.
Applications
- HPAPI & Potent Powder Dispensing/Weighing
- Potent Compound Formulation & Milling
- Pharmaceutical R&D and QC Testing
Class III Biological Safety Cabinet-configured isolators provide maximum biosafety containment for handling Risk Group 3 and 4 biological agents. Featuring a leak-tight physical barrier with glove ports and negative pressure laminar flow, they protect operators from high-consequence pathogens.
Applications
- High-Containment BSL-3 / BSL-4 Laboratories
- Virology & Vaccine Research
- Diagnostic Biological Agent Handling
Designed for hospital and pharmacy compounding in accordance with USP <797> and USP <800> guidelines. Available in Compounding Aseptic Isolator (CAI) models for sterile IV preparation, and Compounding Aseptic Containment Isolator (CACI) models for cytotoxic and antineoplastic chemotherapy drug handling.
Applications
- Hospital Pharmacy Sterile Compounding (CAI)
- Chemotherapy & Cytotoxic Admixture Preparation (CACI)
- Total Parenteral Nutrition (TPN) Formulation
The Cell Processing Isolator (CPI) is an integrated cGMP isolation workstation designed for Advanced Therapy Medicinal Products (ATMP). Combining centrifuge, incubator, and bio-decontamination modules into one closed Grade A system, it optimizes cell therapy manufacturing while eliminating cleanroom overhead.
Applications
- Autologous & Allogeneic Cell Therapy
- Monoclonal Antibody Production & Cell Banking
- cGMP Clinical Trial & Commercial Cell Processing
Esco partners with filling line companies to create client-specific technology, utilizing cGMP compliant isolators and high-quality filling line accessories/technologies to ensure product safety and sterility throughout the entire manufacturing cycle. Enclosures range from Open/Closed Restricted Access Barrier Systems (o/cRABS) to leak-tight isolation technologies.
Applications
- Aseptic Liquid & Powder Vial Filling Lines
- Pre-filled Syringe & Packaging Containment
- Commercial Pharmaceutical & Biopharma Production