Gene Therapy is the introduction of genetic material into a host cell to treat or prevent a disease. It uses sections of DNA (usually genes) to replace the mutated gene and change the expression of protein(s) critical to the development and progress of the disease. In some cases, the whole or part of a gene is defective or missing from birth, or a gene can change or mutate during adult life. Any of these variations can disrupt how proteins are made, which can contribute to health problems or diseases. Scientists can now modify genes or replace faulty genes with healthy ones to potentially treat, cure, or prevent a disease or medical condition.
GENE THERAPY CAN BE PERFORMED BOTH INSIDE AND OUTSIDE OF THE BODY
Gene therapy holds the promise to transform medicine and create options for patients who are living with difficult, and even incurable diseases. To produce the gene therapy product in the most safe and effective way, the laboratory should be well-equipped with top-of-the-line equipment. Some key equipment for gene therapy research includes:
Biological Safety Cabinets
To provide operator protection during gene editing and to protect cultures and genes from outside contaminants.
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AC2-4S9-NS G4
AC2-4S9-NS G4
LA2-4S9 G4
- Energy efficient DC-ECM blower that provides stable airflow to ensure operator safety and aseptic cell culture.
- ULPA filter that is 10x safer than HEPA filter, provides cleaner ISO Class 3 work zone to prevent gene contamination.
- Large performance envelope which provides widest margin for operator and gene protection.
- Antimicrobial coating with silver ions that reduce bioburden and prevent cell culture contamination.
- Raised arm rest to comfortably place arms without grille blocking and to preserve air barrier.
- One-piece interior wall with curved corners for easy cleaning of gene therapy processing residues.
- Centered and angled-down controller that is easy to operate from sitting position.
- UV decontamination to inactivate random nucleic acid contaminants.
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CO₂ Incubators
To maintain optimal environment for the growth of the mammalian cells used in gene therapy.
CCL-170B-9
CCL-170B-9
CCL-170B-9-SS
- Direct heating enables rapid temperature recovery within ≤5 minutes while air jacket provides isolation against ambient temperature fluctuations.
- Excellent CO2, humidity, and temperature uniformity using VentiFlow™ forced convection system.
- ULPA filter that is 10x more efficient than HEPA filter, creating ISO Class 5 chamber within 11 minutes of door closing.
- Advanced heat-resistant Infrared (IR) CO₂ sensor that is not affected by water vapor, pressure, or temperature unlike the TC sensor.
- Validated 90°C moist heat decontamination to get Log 6 kill.
- Easy to remove interior components with rounded corners for quick and thorough surface decontamination.
- User-friendly control panel with large temperature and CO2 display combined with LCD to navigate the menu.
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References:
1. ASGCT – American Society of Gene & Cell Therapy. Gene Therapy Basics. https://patienteducation.asgct.org/gene-therapy-101/gene-therapy-basics
2. Explore Gene Therapy. (n.d.). Get to Know the Different Types of Gene-Based Therapies. https://www.exploregenetherapy.com/how-gene-replacement-therapy-is-different
3. Jack Carfagno. 2019. How Does Gene Therapy Work? Docwire News. https://www.docwirenews.com/docwire-pick/how-does-gene-therapy-work/
4. U.S. Food and Drug Administration. 2017. What Is Gene Therapy? How Does It Work? www.fda.gov/consumers/consumer-updates/what-gene-therapy-how-does-it-work#:~:text=Gene%20therapy%20can%20be%20used,body%20that%20has%20defective%20cells